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pentobarbital will lower the extent or effect of eplerenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.Monitor Intently (one)pentobarbital will decrease the level or effect of tofacitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Loss of, or reduced response to